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BGBR 046

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Drug Profile

BGBR 046

Alternative Names: BGBR-046

Latest Information Update: 20 May 2026

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At a glance

  • Originator BeiGene
  • Developer BeOne Medicines
  • Class Antineoplastics
  • Mechanism of Action Interleukin 15 replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 11 May 2026 BeOne Medicines terminates a phase-I clinical trials in Solid tumours (Monotherapy, Late-stage disease, Metastatic disease, Combination-therapy Inoperable/Unresectable, Second-line therapy or greater) in China (IV), due to a company business decision reflecting a strategic change in the development of BGBR 046 for advanced or metastatic solid tumors (NCT06487858)
  • 25 Apr 2025 Pharmacodynamics data from a pre-clinical study in Cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 18 Jul 2024 Preclinical trials in Solid tumours in China (IV)

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