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ORX 142

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Drug Profile

ORX 142

Alternative Names: ORX-142

Latest Information Update: 27 Jan 2026

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At a glance

  • Originator Centessa Pharmaceuticals
  • Class Sleep disorder therapies; Small molecules
  • Mechanism of Action Orexin receptor type 2 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Hypersomnia

Most Recent Events

  • 13 Jan 2026 Nxera Pharma and Centessa Pharmaceuticals agree to research collaborate for ORX 142 for Neurological disorders
  • 05 Nov 2025 Centessa Pharmaceuticals plans a patient studies for undisclosed indication in 1Q 2025
  • 03 Oct 2025 Phase-I clinical trials in Hypersomnia in USA (In volunteers) (PO) (NCT07082829)

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