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RAP 641

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Drug Profile

RAP 641

Alternative Names: Alpha-6 beta-4 nicotinic acetylcholine receptor agonist - Rapport Therapeutics; RAP-641; α6β4 nAChR - Rapport Therapeutics; α6β4-nAChR agonist - Rapport Therapeutics

Latest Information Update: 16 Jan 2026

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At a glance

  • Originator Rapport Therapeutics
  • Class Antimigraines; Non-opioid analgesics; Small molecules
  • Mechanism of Action CHRNA6 protein agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Migraine; Pain

Most Recent Events

  • 07 Jan 2026 Preclinical trials in Migraine in USA (unspecified route)
  • 07 Jan 2026 Preclinical trials in Pain in USA (unspecified route)
  • 01 Jan 2026 Rapport therapeutics plans a phase I trial in Pain and Migraine

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