Drug Profile

XmAb 657

Alternative Names: CD19 x CD3; XmAb-657

Latest Information Update: 19 Jan 2026

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At a glance

Originator Xencor
Class Anti-inflammatories; Bispecific antibodies
Mechanism of Action Antibody-dependent cell cytotoxicity; Immunologic cytotoxicity

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Myositis

Most Recent Events

31 Dec 2025 Phase-I clinical trials in Myositis (In volunteers) in Australia (SC) (NCT07284797)
16 Dec 2025 Xencor plans a phase I trial for Myositis in Australia (SC, injection) in February 2026 (NCT07284797)
09 Sep 2024 Preclinical trials in Autoimmune disorders in USA (IV)

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