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ZE 74 0282

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Drug Profile

ZE 74 0282

Alternative Names: ZE 74-0282

Latest Information Update: 28 Dec 2025

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At a glance

  • Originator Eilean Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Janus kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Myeloproliferative disorders; Polycythaemia vera
  • Discontinued Cancer

Most Recent Events

  • 17 Dec 2025 Eilean Therapeutics submits an IND application for first-in-human clinical studies of ZE74 0282
  • 17 Dec 2025 Eilean Therapeutics plans a first-in-human clinical trial for myeloproliferative disorders and polycythaemia vera (In volunteers) in the first quarter of 2026
  • 06 Dec 2025 Pharmacokinetic and pharmacodynamics data from preclinical studies presented at the at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)

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