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HDM 2005

Drug Profile

HDM 2005

Alternative Names: HDM-2005

Latest Information Update: 20 Jul 2026

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At a glance

  • Originator Hangzhou Zhongmei Huadong Pharmaceutical
  • Class Antibodies; Antineoplastics; Auristatins; Drug conjugates; Immunotoxins
  • Mechanism of Action Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Diffuse large B cell lymphoma
  • Phase I B-cell lymphoma; Mantle-cell lymphoma; Solid tumours

Most Recent Events

  • 20 Jul 2026 Hangzhou Zhongmei Huadong Pharmaceutical plans a phase Ib/III trial for Mantle cell lymphoma (Combination therapy, Second-line therapy or greater) (IV) (NCT07697339)
  • 06 Dec 2025 Efficacy and adverse events data from a phase I trial in B-Cell Lymphoma presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)
  • 05 Sep 2025 Efficacy and adverse events data from a phase I trial in Mantle cell lymphoma, Diffuse large B-cell lymphoma, B-cell non-Hodgkin lymphoma or classical Hodgkin lymphoma released by Hangzhou Zhongmei Huadong Pharmaceutical

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