HDM 2005
Alternative Names: HDM-2005Latest Information Update: 20 Jul 2026
At a glance
- Originator Hangzhou Zhongmei Huadong Pharmaceutical
- Class Antibodies; Antineoplastics; Auristatins; Drug conjugates; Immunotoxins
- Mechanism of Action Tubulin polymerisation inhibitors
-
Orphan Drug Status
Yes - Mantle-cell lymphoma
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase I/II Diffuse large B cell lymphoma
- Phase I B-cell lymphoma; Mantle-cell lymphoma; Solid tumours
Most Recent Events
- 20 Jul 2026 Hangzhou Zhongmei Huadong Pharmaceutical plans a phase Ib/III trial for Mantle cell lymphoma (Combination therapy, Second-line therapy or greater) (IV) (NCT07697339)
- 06 Dec 2025 Efficacy and adverse events data from a phase I trial in B-Cell Lymphoma presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)
- 05 Sep 2025 Efficacy and adverse events data from a phase I trial in Mantle cell lymphoma, Diffuse large B-cell lymphoma, B-cell non-Hodgkin lymphoma or classical Hodgkin lymphoma released by Hangzhou Zhongmei Huadong Pharmaceutical