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HDM 2005

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Drug Profile

HDM 2005

Alternative Names: HDM-2005

Latest Information Update: 11 Sep 2025

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At a glance

  • Originator Hangzhou Zhongmei Huadong Pharmaceutical
  • Class Antibodies; Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Diffuse large B cell lymphoma
  • Phase I B-cell lymphoma; Mantle-cell lymphoma; Solid tumours

Most Recent Events

  • 05 Sep 2025 Efficacy and adverse events data from a phase I trial in Mantle cell lymphoma, Diffuse large B-cell lymphoma, B-cell non-Hodgkin lymphoma or classical Hodgkin lymphoma released by Hangzhou Zhongmei Huadong Pharmaceutical
  • 31 Jul 2025 US FDA approves CTA application for HDM 2005 in Solid tumours and B-cell lymphoma in USA
  • 30 Jul 2025 Phase-I/II clinical trials in Diffuse large B cell lymphoma (Combination therapy) in China (IV) (NCT07124936)

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