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Lonitoclax - Lomond Therapeutics

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Drug Profile

Lonitoclax - Lomond Therapeutics

Alternative Names: ZE50-0134

Latest Information Update: 31 Dec 2025

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At a glance

  • Originator Lomond Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Chronic lymphocytic leukaemia

Most Recent Events

  • 26 Dec 2025 Lomond Therapeutics plans a phase I trial for Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) (PO, Capsule) in January 2026 (NCT07303660)
  • 23 Jun 2025 US FDA approves IND application for lonitoclax in Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater)
  • 04 Nov 2024 Pharmacodynamics data from preclinical trial in Acute myeloid leukaemia and Chronic lymphocytic leukaemia released by Eilean Therapeutics

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