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CR 003 - Crescent Biopharma

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Drug Profile

CR 003 - Crescent Biopharma

Alternative Names: CR-003 - Crescent Biopharma; PR-023-Paragon Therapeutics; SKB-105

Latest Information Update: 27 Mar 2026

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At a glance

  • Originator Paragon Therapeutics; Sichuan Kelun-Biotech Biopharmaceutical
  • Developer Paragon Therapeutics
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Solid tumours

Most Recent Events

  • 27 Feb 2026 Crescent Biopharma plans to terminates its licence for CR 003 in March 2026
  • 06 Feb 2026 Sichuan Kelun-Biotech Biopharmaceutical plans a phase I/II trial for Solid tumours (Late stage disease) in China (IV, Injection) in April 2026 (NCT07380386)
  • 05 Jan 2026 NMPA approves IND application for CR 003 in Solid tumours

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