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WVE 008

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Drug Profile

WVE 008

Alternative Names: PNPLA3 GalNAc-AIMer -WaVe life Sciences; PNPLA3 targeted GalNAc-AIMer - WaVe life Sciences; WVE-008

Latest Information Update: 31 Aug 2026

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At a glance

  • Originator WaVe life Sciences
  • Class Amines; Amino sugars; Drug conjugates; Hepatoprotectants; Oligonucleotides; Pyrrolidines
  • Mechanism of Action Adiponutrin expression modulators; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Liver disorders

Most Recent Events

  • 30 Jul 2026 Pharmacodynamics data from a preclinical trial in Liver disorder released by WaVe life Sciences
  • 30 Oct 2025 Wave Life Sciences announces intention to submit clinical trial application (CTA) for Liver disorders in 2026
  • 30 Oct 2025 Wave Life Sciences plans a clinical trial for Liver disorders in 2026

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