Drug Profile

WVE 008

Alternative Names: PNPLA3 targeted GalNAc-AIMer - WaVe life Sciences; WVE-008

Latest Information Update: 06 Nov 2025

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At a glance

Originator WaVe life Sciences
Class Amines; Amino sugars; Drug conjugates; Hepatoprotectants; Oligonucleotides; Pyrrolidines
Mechanism of Action Adiponutrin modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Preclinical Liver disorders

Most Recent Events

30 Oct 2025 Wave Life Sciences announces intention to submit clinical trial application (CTA) for Liver disorders in 2026
30 Oct 2025 Wave Life Sciences plans a clinical trial for Liver disorders in 2026
13 Jan 2025 WaVe life Sciences plans a first in human clinical trial for Non-alcoholic-steatohepatitis (Parenteral) in 2026

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