Drug Profile

SYN 818

Alternative Names: SYN-818

Latest Information Update: 11 Sep 2025

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At a glance

Originator SynRx Therapeutics
Class Antineoplastics
Mechanism of Action DNA polymerase theta inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Solid tumours

Most Recent Events

26 Aug 2025 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Combination therapy) in China (PO) (NCT07156253)
25 Apr 2025 SynRx Therapeutics plans a phase Ib/II for solid tumours (Late-stage disease, Metastatic disease, Combination therapy)
25 Apr 2025 Phase-I clinical trials in Solid tumours (Monotherapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO) (Prior to April 2025) (NCT06666270)

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