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SYN 818

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Drug Profile

SYN 818

Alternative Names: SYN-818

Latest Information Update: 06 Jun 2025

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At a glance

  • Originator SynRx Therapeutics
  • Class Antineoplastics
  • Mechanism of Action DNA polymerase theta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 25 Apr 2025 Phase-I clinical trials in Solid tumours (Monotherapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO) (Prior to April 2025) (NCT06666270)
  • 25 Apr 2025 Adverse events and pharmacokinetics data from a phase I trial in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 31 Oct 2024 SynRx Therapeutics plans a phase I trial for Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO), in November 2024 (NCT06666270)

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