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TNG 456

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Drug Profile

TNG 456

Alternative Names: TNG-456

Latest Information Update: 13 Jun 2025

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At a glance

  • Originator Tango Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action PRMT5 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 25 Apr 2025 Pharmacodynamics data from a preclinical study in Cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 24 Mar 2025 Phase-I/II clinical trials in Solid tumours (Combination therapy) in USA (PO) (NCT06810544)
  • 24 Mar 2025 Phase-I/II clinical trials in Solid tumours (Monotherapy) in USA (PO) (NCT06810544)

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