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PF 08046031

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Drug Profile

PF 08046031

Alternative Names: PF-08046031

Latest Information Update: 13 Jun 2025

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At a glance

  • Originator Pfizer
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates; Immunotoxins
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Malignant melanoma; Solid tumours

Most Recent Events

  • 01 May 2025 Phase-I clinical trials in Malignant melanoma (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in USA (IV) (NCT06799533)
  • 01 May 2025 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in USA (IV) (NCT06799533)
  • 25 Apr 2025 Pharmacodynamics data from preclinical trials in Malignant melanoma and Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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