Drug Profile

PLX 61639

Alternative Names: PLX-61639

Latest Information Update: 27 Aug 2026

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At a glance

Originator Plexium
Class Antineoplastics; Small molecules
Mechanism of Action SMARCA2 protein degraders

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Solid tumours

Most Recent Events

22 Apr 2026 Pharmacodynamics data from a preclinical studies in Solid tumours presented at the 117th Annual Meeting of the American Association for Cancer Research (AACR-2026)
02 Dec 2025 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT07284186)
27 Feb 2025 Preclinical trials in Solid tumours in USA (PO) prior to February 2025 (Plexium pipeline, February 2025)

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