Drug Profile

ENX 205

Latest Information Update: 02 Dec 2025

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At a glance

Originator Engrail Therapeutics
Class Anxiolytics; Mood stabilisers
Mechanism of Action 5-HT1A serotonin receptor agonists; Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists; Serotonin 5-HT2A receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

23 May 2025 Phase-I clinical trials in Mood disorders (In volunteers) in United Kingdom (PO) (NCT07253246)
23 May 2025 Phase-I clinical trials in Post-traumatic stress disorders (In volunteers) in United Kingdom (PO) (NCT07253246)
28 Feb 2025 Preclinical trials in Mood disorders in USA (unspecified route) (Engrail Therapeutics pipeline, February 2025)

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