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QCZ 484

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Drug Profile

QCZ 484

Alternative Names: QCZ-484

Latest Information Update: 13 Feb 2026

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At a glance

  • Originator Novartis Pharmaceuticals
  • Class Antihypertensives; RNA
  • Mechanism of Action RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hypertension

Most Recent Events

  • 31 Dec 2025 Novartis intends to file regulatory applications for approval of QCZ 484 in Hypertension in or after 2029 (Novartis pipeline, December 2025)
  • 01 Jul 2025 Novartis Pharmaceuticals completes a phase I trial in Hypertension in New Zealand and Australia (SC) (NCT06905327)
  • 26 Mar 2025 Phase-II clinical trials in Hypertension in Japan (SC) (NCT06857955)

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