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Sapanisertib/Serabelisib - Sensei Biotherapeutics

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Drug Profile

Sapanisertib/Serabelisib - Sensei Biotherapeutics

Alternative Names: FTH-001 + FTH-003; FTH-001/003; FTH-001/FTH-003; FTH-003/FTH-001; Serabelisib/Sapanisertib

Latest Information Update: 09 Mar 2026

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At a glance

  • Originator Faeth Therapeutics
  • Developer Sensei Biotherapeutics
  • Class 2 ring heterocyclic compounds; Alkanes; Amines; Antineoplastics; Benzoxazoles; Imidazoles; Ketones; Morpholines; Pyrazoles; Pyrazolones; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Endometrial cancer
  • Phase I Solid tumours

Most Recent Events

  • 09 Mar 2026 Chemical structure information added.
  • 19 Feb 2026 Faeth Therapeutics has been acquired and merged into Sensei Biotherapeutics
  • 18 Feb 2026 Efficacy data from the phase Ib trial in Solid tumours released by Sensei Biotherapeutics

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