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MRT 51443

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Drug Profile

MRT 51443

Alternative Names: MRT-51443

Latest Information Update: 10 Jul 2025

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At a glance

  • Originator Monte Rosa Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 2 modulators; Proteolysis; Ubiquitin protein ligase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical HER2 negative breast cancer

Most Recent Events

  • 28 Apr 2025 Monte Rosa Therapeutics announces its intention to submit an IND application in 2026
  • 28 Apr 2025 Preclinical trials in HER2-negative-breast-cancer in USA (unspecified route), prior to April 2025
  • 28 Apr 2025 Pharmacodynamics data from preclinical studies in HER2-negative-breast-cancer released by Monte Rosa Therapeutics

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