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Ondansetron/Pramipexole - Alto Neuroscience

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Drug Profile

Ondansetron/Pramipexole - Alto Neuroscience

Alternative Names: ALTO-207; CTC-501; Pramipexole/Ondansetron - Alto Neuroscience

Latest Information Update: 13 Apr 2026

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At a glance

  • Originator Chase Therapeutics
  • Class Antidepressants; Benzothiazoles; Carbazoles; Imidazoles; Small molecules
  • Mechanism of Action Dopamine D2 receptor agonists; Dopamine D3 receptor agonists; Serotonin 5 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Major depressive disorder

Most Recent Events

  • 01 Apr 2026 Alto Neuroscience plans a phase IIb trial for Treatment resistant depressive disorder (Adjunctive treatment, Treatment experienced) (PO) in first half of 2026
  • 16 Mar 2026 Bayer announces intention to submit NDA for Treatment resistant depressive disorder
  • 14 Jan 2026 US PTO issued a patent covering methods of treating depression with ondansetron/pramipexole

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