Drug Profile

SPY 072

Alternative Names: SPY0-72; SPY002-072

Latest Information Update: 04 Jul 2025

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At a glance

Originator Spyre Therapeutics
Class Anti-inflammatories; Antirheumatics; Monoclonal antibodies
Mechanism of Action Tumour necrosis factor ligand superfamily member 15 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

17 Jun 2025 Spyre Therapeutics plans the phase II SKYWAY-RD trial for Rheumatoid arthritis, Psoriatic arthritis and Axial spondylarthritis in third quarter of 2025
18 Nov 2024 Phase-I clinical trials in Axial spondyloarthritis (In volunteers) in USA, Canada (SC) (NCT06622070) (Spyre Therapeutics Pipeline, June 2025)
18 Nov 2024 Phase-I clinical trials in Psoriatic arthritis (In volunteers) in USA, Canada (SC) (NCT06622070) (Spyre Therapeutics Pipeline, June 2025)

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