Drug Profile

Nectin 4 targeting antibody drug conjugate - Araris Biotech

Alternative Names: triple MMAE/dual TOP1i payload ADC; triple-warhead ADC

Latest Information Update: 01 Aug 2025

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At a glance

Originator Araris Biotech
Class Antineoplastics; Drug conjugates; Immunoconjugates
Mechanism of Action DNA topoisomerase I inhibitors; Mitosis inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Preclinical Solid tumours

Most Recent Events

25 Apr 2025 Preclinical trials in Solid tumours in Switzerland (Parenteral) before April 2025
25 Apr 2025 Pharmacodynamics, pharmacokinetics and safety data from a preclinical trial in Solid tumours presented at the 116^th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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