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CEACAM-5 immune stimulating antibody conjugate - Bolt Biotherapeutics

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Drug Profile

CEACAM-5 immune stimulating antibody conjugate - Bolt Biotherapeutics

Alternative Names: CEA ISAC; CEA-targeted ISAC

Latest Information Update: 04 Apr 2026

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At a glance

  • Originator Bolt Biotherapeutics
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates
  • Mechanism of Action Toll-like receptor 7 agonists; Toll-like receptor 8 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Suspended Colorectal cancer; Non-small cell lung cancer

Most Recent Events

  • 12 Mar 2026 Bolt Therapeutics plans to initiate clinical trials within 18 months of development resumption
  • 12 Mar 2026 Suspended - Preclinical for Colorectal cancer in USA (Parenteral) as Bolt Therapeutics seek partnership or funding
  • 12 Mar 2026 Suspended - Preclinical for Non-small cell lung cancer in USA (Parenteral) as Bolt Therapeutics seek partnership or funding

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