Drug Profile

Exon 45 based oligonucleotide-antibody conjugate - exon 45 - Dyne Therapeutics

Latest Information Update: 04 Dec 2025

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At a glance

Originator Dyne Therapeutics
Class Antibodies; Antisense oligonucleotides; Drug conjugates; Immunoconjugates
Mechanism of Action Dystrophin expression stimulants; Gene silencing

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

24 Apr 2025 Preclinical trials in Duchenne muscular dystrophy in USA (Parenteral), prior to April 2025

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