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KQB 548

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Drug Profile

KQB 548

Alternative Names: BAY-3771249; KQB-548

Latest Information Update: 31 Oct 2025

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At a glance

  • Originator Kumquat Biosciences
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 18 Sep 2025 Preclinical trials in Solid tumours in USA (unspecified route), prior to September 2025 (Kumquat Biosciences pipeline, September 2025)
  • 16 Sep 2025 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease) in USA (PO) (NCT07207707)
  • 12 Aug 2025 KRAS G12D inhibitor licensed to Bayer worldwide

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