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HMPL A251

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Drug Profile

HMPL A251

Alternative Names: HMPL-A251

Latest Information Update: 23 Dec 2025

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At a glance

  • Originator HUTCHMED
  • Class Antineoplastics; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 16 Dec 2025 Phase-I/II clinical trials in Solid tumours (Inoperable/Unresectable, Metastatic disease, Late-stage disease) in USA, China (IV, Infusion) (NCT07228247)
  • 07 Nov 2025 HMPL A251 is available for licensing as of 03 Nov 2025. https://www.hutch-med.com/pipeline-and-products/our-pipeline/
  • 23 Oct 2025 HUTCHMED plans phase-I/II trial for Solid tumours (Late-stage disease, Metastatic, Monotherapy, Unresectable/Inoperable, Second-line therapy or greater) in USA and China (IV, infusion) in December 2025 (NCT07228247)

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