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SB 19642

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Drug Profile

SB 19642

Alternative Names: SB-19642; SBH-19642

Latest Information Update: 03 Nov 2025

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At a glance

  • Originator The Childrens Hospital of Philadelphia
  • Developer SynaptixBio
  • Class Antisense oligonucleotides
  • Mechanism of Action Gene silencing; TUBB4A protein expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypomyelinating leukodystrophy-6
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Hypomyelinating leukodystrophy-6

Most Recent Events

  • 31 Oct 2025 SB 19642 is available for licensing as of 31 Oct 2025. https://www.synaptixbio.com/the-opportunity
  • 31 Oct 2025 Synaptix Bio has a patent protection for SB 19642 worldwide (Synaptix Bio pipeline, October 2025)
  • 31 Oct 2025 Phase-I clinical trials in Hypomyelinating leukodystrophy 6 (Intrathecal) before October 2025 (Synaptix Bio pipeline, October 2025)

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