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APVO 451

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Drug Profile

APVO 451

Alternative Names: APVO-451

Latest Information Update: 06 Nov 2025

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At a glance

  • Originator Aptevo Therapeutics
  • Class Antineoplastics; Immunotherapies; Trispecific antibodies
  • Mechanism of Action T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Solid tumours

Most Recent Events

  • 24 Oct 2025 APVO 451 is available for licensing as of 24 Oct 2025. https://aptevotherapeutics.com/about-us/
  • 24 Oct 2025 Preclinical trials in Solid tumours in USA (Parenteral) (Aptevo Therapeutics pipeline, October 2025)
  • 04 Sep 2025 Aptevo Therapeutics files for patent protection with the U.S. Patent and Trademark Office for APVO452 in USA

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