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ORM 1153

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Drug Profile

ORM 1153

Alternative Names: ORM-1153

Latest Information Update: 12 Dec 2025

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At a glance

  • Originator Orum Therapeutics
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates
  • Mechanism of Action Peptide-chain-release factor 3 degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Haematological malignancies

Most Recent Events

  • 08 Dec 2025 Pharmacodynamics and adverse events data from a preclinical trial in Acute myeloid leukemia released by Orum Therapeutics
  • 06 Dec 2025 Pharmacodynamics and adverse events data from a preclinical trial in Acute myeloid leukemia presented at 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)
  • 07 Nov 2025 Orum Therapeutics plans to submit IND in Haematological malignancies in the second half of 2026

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