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KB 111

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Drug Profile

KB 111

Alternative Names: KB-111

Latest Information Update: 20 Feb 2026

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At a glance

  • Originator Krystal Biotech
  • Class Gene therapies; Skin disorder therapies
  • Mechanism of Action ATP2C1 protein replacements; Gene transference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Preclinical Benign Familial Pemphigus

Most Recent Events

  • 17 Feb 2026 Krystal Biotech plans a registrational trial for Benign familial pemphigus in the second half of 2026
  • 01 Jan 2026 KB 111 receives Fast Track designation for Benign familial pemphigus [Topical] in USA
  • 13 Nov 2025 Pharmacodynamics data from a preclinical study in Hailey-hailey disease released by Krystal Biotech prior to November 2025

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