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PRT 12396 - Prelude Therapeutics

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Drug Profile

PRT 12396 - Prelude Therapeutics

Alternative Names: JAK2V617F mutant selective JH2 inhibitor - Prelude Therapeutics; PRT-12396

Latest Information Update: 09 Feb 2026

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At a glance

  • Originator Prelude Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Janus kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Myeloproliferative disorders

Most Recent Events

  • 03 Feb 2026 Prelude Therapeutics receives clearance from the US FDA for IND application for PRT 12396 for the treatment of Myeloproliferative disorders
  • 06 Dec 2025 Prelude Therapeutics plans a phase I trial for Myeloproliferative disorders in the first quarter of 2026
  • 06 Dec 2025 Pharmacodynamic and adverse events data from a preclinical studies in Myeloproliferative disorder released by Prelude Therapeutics

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