Drug Profile

TAK 781

Alternative Names: TAK-781

Latest Information Update: 05 Feb 2026

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At a glance

Originator Takeda
Class Amides; Amino acids; Amino sugars; Anti-inflammatories; Drug conjugates; Hepatoprotectants; Small interfering RNA
Mechanism of Action Cholesterol 7-alpha-hydroxylase expression inhibitors; Gene silencing

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

07 Jan 2026 Phase-I clinical trials in Primary sclerosing cholangitis in USA (Parenteral) (NCT07229911)
17 Nov 2025 Preclinical trials in Primary sclerosing cholangitis in Japan (Parenteral)
17 Nov 2025 Takeda plans a phase I trial for Primary sclerosing cholangitis in USA (Parenteral, Injection) in December 2025 (NCT07229911)

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