Research programme: TDP-43 targeting small molecule therapeutics - Transition Bio/Voyager
Latest Information Update: 28 Nov 2025
At a glance
- Originator Transition Bio
- Class Antidementias; Small molecules
- Mechanism of Action TDP-43 protein modulators
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Orphan Drug Status
No
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Research Amyotrophic lateral sclerosis; Frontotemporal dementia
Most Recent Events
- 10 Nov 2025 Transition Bio and Voyager enters into a collaboration and license option agreement to develop small molecules targeting TDP-43 for Amyotrophic lateral sclerosis and Frontotemporal dementia
- 10 Nov 2025 Early research in Amyotrophic lateral sclerosis in USA (unspecified route)
- 10 Nov 2025 Early research in Frontotemporal dementia in USA (unspecified route)