Drug Profile

Research programme: SMARCA4 targeted antibody drug conjugates - AbCellera/Prelude Therapeutics

Latest Information Update: 21 Jan 2026

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At a glance

Originator Abcellera; Prelude Therapeutics
Class Antineoplastics; Drug conjugates; Immunoconjugates; Monoclonal antibodies
Mechanism of Action SMARCA4 protein degraders

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

04 Nov 2025 Early research in Cancer in Canada (Parenteral), prior to November 2025
04 Nov 2025 Early research in Cancer in USA (Parenteral), prior to November 2025
01 Nov 2023 Prelude Therapeutics and AbCellera enters into an agreement to develop antibody drug conjugates for cancer (Prelude Therapeutics pipeline, November 2025)

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