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KRRO 121

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Drug Profile

KRRO 121

Alternative Names: KRRO-121

Latest Information Update: 29 Jan 2026

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At a glance

  • Originator Korro Bio
  • Class Hepatoprotectants; Oligonucleotides
  • Mechanism of Action Protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Hepatic encephalopathy; Hyperammonaemia; Inborn urea cycle disorders

Most Recent Events

  • 20 Jan 2026 Korro Bio announces intention to submit regulatory application for Hyperammonaemia in second half of 2026
  • 13 Nov 2025 Korro Bio anticipates a clinical trial in the second half of 2026
  • 12 Nov 2025 Preclinical trials in Hyperammonaemia in USA (SC), prior to November 2025

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