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RG 6496

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Drug Profile

RG 6496

Alternative Names: RG-6496

Latest Information Update: 11 Feb 2026

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At a glance

  • Originator Ionis Pharmaceuticals
  • Developer Roche
  • Class Antisense oligonucleotides; Neuroprotectants
  • Mechanism of Action Huntingtin protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Huntington's disease

Most Recent Events

  • 29 Jan 2026 RG 6496 licensed to Roche (Roche pipeline, January 2026)
  • 19 Nov 2025 Phase-I clinical trials in Huntington's disease in New Zealand (Intrathecal) (NCT07246941)

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