Drug Profile

ISM 8969

Alternative Names: ISM-8969

Latest Information Update: 27 Jan 2026

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At a glance

Originator InSilico Medicine
Developer Hygtia Therapeutics; InSilico Medicine
Class Anti-inflammatories; Antiparkinsonians; Neuroprotectants; Small molecules
Mechanism of Action NLRP3 protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Preclinical Parkinson's disease

Most Recent Events

23 Jan 2026 Preclinical trials in Parkinson's disease in USA (PO), prior to January 2026 (Insilico Medicine pipeline, January 2026)
23 Jan 2026 Insilico Medicine files an IND application with the US FDA in USA for Parkinson's disease (Insilico Medicine website, January 2026)
20 Jan 2026 ISM 8969 licensed to Hygtia Therapeutics worldwide

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