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ZW 427

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Drug Profile

ZW 427

Alternative Names: ZW-427

Latest Information Update: 24 Apr 2026

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At a glance

  • Originator Zymeworks
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates
  • Mechanism of Action Ras protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Solid tumours

Most Recent Events

  • 24 Apr 2026 ZW 427 is available for licensing as of 24 Apr 2026. https://www.zymeworks.com/partners/ (Zymeworks Pipeline, April 2026)
  • 17 Apr 2026 Pharmacodynamics and adverse event data from a preclinical trial in Solid tumour released by Zymeworks
  • 17 Mar 2026 Preclinical trials in Solid tumours in Canada (Parenteral), before March 2025

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