Buprenorphine/methadone/oxymorphone
Precipitated opiate withdrawal syndrome following initiation of high-dose buprenorphine, prescribed without adequate wash-out of methadone and oxymorphone: case report-
Serious
An event is determined to be serious (based on the ICH definition) when the patient outcome is:
death
life-threatening
hospitalisation
disability
congenital anomaly
other medically important event