Alendronic-acid/sarilumab
Medication-related osteonecrosis of the jaw, necrotising fasciitis and Bacteroides pyogenes infection- 
            
              SeriousAn event is determined to be serious (based on the ICH definition) when the patient outcome is: 
 death
 life-threatening
 hospitalisation
 disability
 congenital anomaly
 other medically important event
