Multiple drugs
Treatment non-compliance, rebound effect in the form of chronic myeloid leukaemia progression into acute mixed lineage leukaemia (acute myeloid leukaemia) and lack of efficacy: case report-
Serious
An event is determined to be serious (based on the ICH definition) when the patient outcome is:
death
life-threatening
hospitalisation
disability
congenital anomaly
other medically important event