Bevacizumab/Protein tyrosine kinase inhibitors
Gastrointestinal haemorrhage, gastric ulcer, hepatic enzyme elevations, proteinuria, diarrhoea, hand-foot syndrome, and reactive cutaneous capillary endothelial proliferation: 65 case reports-
Serious
An event is determined to be serious (based on the ICH definition) when the patient outcome is:
death
life-threatening
hospitalisation
disability
congenital anomaly
other medically important event