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First prospective intergroup translational research trial assessing the potential predictive value of p53 using a functional assay in yeast in patients with locally advanced/inflammatory or large operable breast cancer prospectively randomised to a taxane versus a non taxane regimen.

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First prospective intergroup translational research trial assessing the potential predictive value of p53 using a functional assay in yeast in patients with locally advanced/inflammatory or large operable breast cancer prospectively randomised to a taxane versus a non taxane regimen.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Dec 2023

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At a glance

  • Drugs Docetaxel (Primary) ; Epirubicin (Primary) ; Cyclophosphamide; Cyclophosphamide; Filgrastim; Fluorouracil
  • Indications Advanced breast cancer
  • Focus Biomarker; Therapeutic Use

    • Most Recent Events

    • 24 Oct 2023 Results of a sub-study with log-term follow-up assessing immune landscape in early BC at a multiplex and spatial resolution using machine learning (ML)-based algorithms and investigating its potential prognostic value using tissue microarrays (TMA) pretreatment samples obtained from patients enrolled in this trial presented at the 48th European Society for Medical Oncology Congress
    • 19 Jul 2012 Actual patient number changed from 798 to 1856 as reporeted by ClinicalTrials.gov.
    • 27 May 2010 Planned end date (6 Nov 2006) added as reported by United Kingdom Clinical Research Network.

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