Trial Profile
A Randomized, Three Arm Multinational Phase III Study to Investigate Bevacizumab (q3w or q2w) in Combination With Either Intermittent Capecitabine Plus Oxaliplatin (XELOX) (q3w) or Fluorouracil/ Leucovorin With Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 Regimen Alone as Adjuvant Chemotherapy in Colon Carcinoma
Status:
Completed
Phase of Trial:
Phase III
Latest Information Update: 31 Dec 2021
Price :
$35
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At a glance
- Drugs Bevacizumab (Primary) ; Capecitabine; Fluorouracil; Folinic acid; Oxaliplatin
- Indications Carcinoma; Colon cancer
- Focus Biomarker; Registrational; Therapeutic Use
- Acronyms AVANT
- Sponsors Roche
- 01 Feb 2020 Results published in the Annals of Oncology
- 16 Jan 2020 Results (n=6501) of pooled analysis of six clinical trials (NCT00079274; NCT00096278; NCT00004931; NCT00275210; NCT00265811; NCT00112918) examining the change of outcomes over 10-year period in patients with stage 3 colon cancer who were treated with fluorouracil, leucovorin, and oxaliplatin in the ACCENT database, published in the Annals of Oncology.
- 14 May 2018 Results (n=3451) assessing the predictive potential of TSR, by determining the effects on DFS and OS in patients with high-risk stage II and stage III colon cancer who received standard oxaliplatin-based chemotherapy with or without addition of bevacizumab, were published in the British Journal of Cancer.