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An Evaluation of the Toxicity and Therapeutic Effects of Epstein-Barr Virus-Immune T-Lymphocytes Derived From a Normal HLA-Compatible or Haplotype-Matched Donor in the Treatment of EBV-Associated Lymphoproliferative Diseases or Malignancies and Patients With Detectable Circulating Levels of EBV DNA Who Are at High Risk for EBV-Associated Lymphoproliferative Diseases

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Trial Profile

An Evaluation of the Toxicity and Therapeutic Effects of Epstein-Barr Virus-Immune T-Lymphocytes Derived From a Normal HLA-Compatible or Haplotype-Matched Donor in the Treatment of EBV-Associated Lymphoproliferative Diseases or Malignancies and Patients With Detectable Circulating Levels of EBV DNA Who Are at High Risk for EBV-Associated Lymphoproliferative Diseases

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 04 Dec 2023

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At a glance

  • Drugs Tabelecleucel (Primary)
  • Indications B-cell lymphoma; Cancer; Carcinoma; Diffuse large B cell lymphoma; Haemophagocytic lymphohistiocytosis; Hodgkin's disease; Leiomyosarcoma; Lymphoma; Lymphoproliferative disorders; Nasopharyngeal cancer; Non-Hodgkin's lymphoma; Post-transplant lymphoproliferative disorder
  • Focus Registrational; Therapeutic Use
  • Sponsors Atara Biotherapeutics
  • Most Recent Events

    • 29 Nov 2023 According to an Atara Biotherapeutics media release, pooled analysis of four single-arm, open-label studies, (NCT04554914, NCT00002663, NCT01498484 and multicenter, expanded-access protocol NCT02822495) (n=18), will be presented as an oral session at the European Society for Medical Oncology Immuno-Oncology (ESMO I-O) Annual Congress, 2023.
    • 29 Nov 2023 Results presented in an Atara Biotherapeutics media release.
    • 13 Dec 2022 Results evaluating efficacy and safety of Tabelecleucel presented at the 64th American Society of Hematology Annual Meeting and Exposition
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