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A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Study Comparing GW572016 and Letrozole Versus Letrozole in Subjects With Estrogen/Progesterone Receptor- Positive Advanced or Metastatic Breast Cancer

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Trial Profile

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Study Comparing GW572016 and Letrozole Versus Letrozole in Subjects With Estrogen/Progesterone Receptor- Positive Advanced or Metastatic Breast Cancer

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 05 Sep 2023

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At a glance

  • Drugs Lapatinib (Primary) ; Letrozole
  • Indications Advanced breast cancer
  • Focus Registrational; Therapeutic Use
  • Sponsors GlaxoSmithKline; GSK; Novartis Pharmaceuticals

    • Most Recent Events

    • 10 Mar 2022 This trial has been discontinued in Italy, according to European Clinical Trials Database record.
    • 22 Sep 2020 Results from NCT00073528 (n=484) and NCT00863655 (n=261 ) developing prognostic model based on PAM50 and clinical variables (PAM50MET) for metastatic HER2-negative breast cancer, published in the Clinical Cancer Research
    • 18 Jun 2018 Status changed from active, no longer recruiting to completed.

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