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A phase IA/II multicenter, dose-escalation study of oral AMN107 on a continuous daily dosing schedule in adult patients with imatinib -resistant/intolerant CML in chronic or accelerated phase or blast crisis, relapsed/refractory Ph+ ALL, and other hematologic malignancies.

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A phase IA/II multicenter, dose-escalation study of oral AMN107 on a continuous daily dosing schedule in adult patients with imatinib -resistant/intolerant CML in chronic or accelerated phase or blast crisis, relapsed/refractory Ph+ ALL, and other hematologic malignancies.

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 03 Nov 2021

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At a glance

  • Drugs Nilotinib (Primary)
  • Indications Chronic myeloid leukaemia; Haematological malignancies; Hypereosinophilic syndrome; Precursor cell lymphoblastic leukaemia-lymphoma; Systemic mastocytosis
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
  • Sponsors Novartis; Novartis Pharmaceuticals

    • Most Recent Events

    • 02 Aug 2012 Planned number of patients changed from 907 to 965 as reported by ClinicalTrials.gov.
    • 02 Aug 2012 Planned end date changed from 1 May 2014 to 1 Sep 2012 as reported by ClinicalTrials.gov.
    • 01 Jun 2012 Planned end date changed from 1 Aug 2012 to 1 May 2014 as reported by ClinicalTrials.gov.

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