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A phase III randomized study (phase I closed) of radiation therapy and temozolomide versus radiation therapy and nitrosourea [carmustine, lomustine] for anaplastic astrocytoma and mixed anaplastic oligoastrocytoma (astrocytoma dominant)

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Trial Profile

A phase III randomized study (phase I closed) of radiation therapy and temozolomide versus radiation therapy and nitrosourea [carmustine, lomustine] for anaplastic astrocytoma and mixed anaplastic oligoastrocytoma (astrocytoma dominant)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 03 Nov 2021

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At a glance

  • Drugs Carmustine polifeprosan 20 wafer (Primary) ; Lomustine (Primary) ; Temozolomide (Primary)
  • Indications Anaplastic astrocytoma; Glioma
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 15 May 2018 Status changed from active, no longer recruiting to completed.
    • 21 Dec 2017 Planned End Date changed from 1 Mar 2020 to 1 Feb 2020.
    • 07 Jun 2016 Results examining the prognostic value of mutations within IDH1/2, ATRX, CIC, FUBP1, and the TERT promoter in a phase III study of grade III astrocytomas using multivariate analyses presented at the 52nd Annual Meeting of the American Society of Clinical Oncology
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