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A Randomized Phase III Multicenter Trial of Neoadjuvant Docetaxel (Taxotere) Plus Cisplatin and 5-Fluorouracil (TPF) Versus Neoadjuvant Cisplatin Plus 5-Fluorouracil Followed by Concomitant Chemoradiotherapy to Improve the Overall Survival and Progression Free Survival in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

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Trial Profile

A Randomized Phase III Multicenter Trial of Neoadjuvant Docetaxel (Taxotere) Plus Cisplatin and 5-Fluorouracil (TPF) Versus Neoadjuvant Cisplatin Plus 5-Fluorouracil Followed by Concomitant Chemoradiotherapy to Improve the Overall Survival and Progression Free Survival in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 25 Mar 2011

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At a glance

  • Drugs Docetaxel (Primary) ; Cisplatin; Fluorouracil
  • Indications Head and neck cancer
  • Focus Registrational; Therapeutic Use
  • Sponsors Sanofi

    • Most Recent Events

    • 08 Oct 2010 Five-year results have been presented at the 35th Congress of the European Society for Medical Oncology (ESMO).
    • 12 Oct 2009 Five-year follow-up results have been presented at the 15th European Cancer Conference and the 34th Congress of the European Society for Medical Oncology.
    • 18 Sep 2005 New trial record.

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