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A 2x2 Factorial Randomized Phase III Study of Intermittent Oral Capecitabine in Combination With Intravenous Oxaliplatin (Q3W) ("XELOX") With/Without Intravenous Bevacizumab (Q3W) Versus Bolus and Continuous Infusion Fluorouracil/Intravenous Leucovorin With Intravenous Oxaliplatin (Q2W) ("FOLFOX-4") With/Without Intravenous Bevacizumab (Q2W) as First-line Treatment for Patients With Metastatic Colorectal Cancer

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Trial Profile

A 2x2 Factorial Randomized Phase III Study of Intermittent Oral Capecitabine in Combination With Intravenous Oxaliplatin (Q3W) ("XELOX") With/Without Intravenous Bevacizumab (Q3W) Versus Bolus and Continuous Infusion Fluorouracil/Intravenous Leucovorin With Intravenous Oxaliplatin (Q2W) ("FOLFOX-4") With/Without Intravenous Bevacizumab (Q2W) as First-line Treatment for Patients With Metastatic Colorectal Cancer

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 08 Dec 2018

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At a glance

  • Drugs Bevacizumab (Primary) ; Capecitabine; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Colorectal cancer
  • Focus Registrational; Therapeutic Use
  • Sponsors Roche

    • Most Recent Events

    • 29 Nov 2018 Results (n=1590) of retropsective sub group analysis of AVF2107g and NO16966 studies, published in the British Journal of Cancer.
    • 20 Jan 2018 Results (n=2214) of exploratory subgroup analysis assessing improved progression free survival with Bevacizumab plus chemotherapy from the data of this trial and other phase III study presented at the 2018 Gastrointestinal Cancers Symposium.
    • 15 Jan 2018 Results from two cohorts of metastatic colorectal cancer (a nonrandomized exploratory cohort n=184 and confirmatory cohort n=200 ) published in the Journal of the National Cancer Institute

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